Physicochemical Property Testing — OECD TG 105 Water Solubility

Decoding Environmental Behavior: Defining the Limits of Solubility

Water solubility is a fundamental property that dictates how a chemical substance partitions between the environment's biotic and abiotic compartments. It is a key determinant for bioaccumulation, biodegradation, and aquatic toxicity. Weshin offers comprehensive OECD TG 105 Water Solubility testing services, ensuring high-quality data that meets the stringent requirements of REACH, GHS, and other global regulatory frameworks.
 

Our Technical Excellence

• Methodological Flexibility: We provide validated testing paths based on the substance’s expected solubility profile:

  • Flask Method: The gold standard for substances with solubility > 10 mg/L, utilizing controlled agitation to reach thermodynamic equilibrium.

  • Column Elution Method: Specialized for low-solubility substances (< 10 mg/L), ensuring precise measurement through micro-solubility detection techniques.

• Advanced Analytical Support: Integration with high-resolution analytical platforms such as HPLC-DAD/MS, GC-FID, and TOC to ensure the lowest detection limits and highest repeatability.

• Rigorous Environmental Control: Precise temperature regulation  and the ability to conduct pH-dependent solubility studies to simulate real-world environmental conditions.

• Strategic Consulting: Expert guidance on sample preparation for complex, multi-component, or highly hydrophobic substances.
   

Application Scope

Essential for pure substances, agrochemicals, and specialty chemicals. Accurate solubility data is indispensable for Environmental Risk Assessments (ERA) and Safety Data Sheet (SDS) Section 9 documentation.


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