Bioaccumulation Potential Assessment — OECD TG 107 Partition Coefficient (Shake Flask Method)

Balancing Lipophilicity: The Key to Predicting Biological and Environmental Fate

The n-octanol/water partition coefficient ($P_{ow}$) is a fundamental parameter used to evaluate how a chemical substance partitions between lipids and water. It serves as a primary indicator for bioaccumulation potential, membrane permeability, and environmental distribution. Weshin provides high-quality OECD TG 107 Shake Flask services, delivering the reliable $\log P_{ow}$ data essential for global regulatory compliance, including REACH, TSCA, and GHS.
 

Our Technical Excellence

• The Thermodynamic Gold Standard: The Shake Flask method remains the definitive approach for determining the partition coefficient. We achieve precise thermodynamic equilibrium through controlled agitation and meticulous temperature regulation.

• Superior Phase Separation: Leveraging high-speed centrifugation to ensure complete separation of octanol and aqueous phases, effectively eliminating errors caused by micro-emulsion formation.

• Optimized Dynamic Range: Ideally suited for pure substances with values ranging from -2 to 4, providing robust data that serves as the basis for further toxicological assessments.

• Analytical Precision: Utilizing advanced analytical platforms (HPLC-DAD/MS, GC-FID, etc.) to perform independent concentration measurements in both phases, ensuring rigorous mass balance validation.

• pH-Adjusted Evaluations: For ionizable substances, we conduct tests across various pH levels to determine the distribution coefficient ($D_{ow}$), reflecting the substance’s behavior in different physiological and environmental matrices.
   

Application Scope

Essential for pure chemicals, agrochemicals, and pharmaceutical compounds. This data is critical for Safety Data Sheet (SDS) Section 12, Environmental Risk Assessments (ERA), and PBT (Persistent, Bioaccumulative, and Toxic) screenings.


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