OECD TG-112 Dissociation Constants in Water
OECD GLP Physical-Mechanical Test
WESHIN INSPECTION TECH CO., LTD_

OECD TG 112: Dissociation Constants in Water (pKa)

 

Unlocking the ionization profile of chemical substances for superior environmental and biological risk assessment.

The dissociation state of a substance in an aqueous environment is a fundamental parameter that dictates its solubility, permeability, and overall behavior. At Weshin Inspection Tech , we provide high-precision dissociation constant  pKa determination in strict accordance with OECD Test Guideline 112 (TG 112).

 

The Critical Role of pKa Data

 

Understanding the pKa of a chemical is essential for predicting how it will interact with various biological and environmental systems. Our data supports:

  • Environmental Fate Prediction: Estimating mobility in soil and water based on ionization states at environmental $pH$ (typically 4–9).

  • Bioavailability Studies: Predicting the absorption and distribution of chemicals within living organisms.

  • Formulation Development: Optimizing the stability and efficacy of chemical products in aqueous solutions.

  • Regulatory Dossiers: Meeting mandatory physical-chemical data requirements for REACH and other global chemical inventories.
     

Our Testing Methodologies

 

Weshin Inspection Tech employs industry-leading techniques as specified in OECD TG 112:

  • Titration Method: The preferred approach for substances with sufficient water solubility and detectable acid-base properties.

  • Spectrophotometric Method: Ideal for substances with $pH$-dependent UV-Vis absorption, offering high sensitivity for samples with low solubility.

  • Conductometric Method: Utilized for specific electrolytes to ensure accurate measurement across diverse chemical classes.
     

Why Partner with Weshin Inspection Tech?

 

  • Scientific Rigor: Our laboratory maintains strict temperature-controlled environments to deliver reliable data with minimal uncertainty.

  • Expert Interpretation: We go beyond raw data, providing detailed analytical reports with $pKa$ curves and mathematical derivations ready for regulatory audit.

  • Bespoke Support: Whether your substance is highly acidic, basic, or amphoteric, our technical team provides the expertise needed to navigate complex dissociation profiles.


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