OECD TG-116 Fat Solubility of Solid and Liquid Substances
OECD GLP Physical-Mechanical Test
WESHIN INSPECTION TECH CO., LTD_

OECD TG 116: Fat Solubility of Solid and Liquid Substances

 

Characterizing lipophilic properties to predict biological accumulation and tissue distribution.

The solubility of a substance in fats (lipids) is a critical parameter for evaluating its bioaccumulation potential and toxicokinetic behavior. At Weshin Inspection Tech , we conduct high-precision fat solubility studies in strict accordance with OECD Test Guideline 116 (TG 116), quantifying the mass of a substance that can be dissolved in a standardized lipid solvent.


The Importance of Fat Solubility Data

 

Determining the extent to which a substance partitions into fats is essential for comprehensive risk assessment:

  • Bioaccumulation Assessment: High fat solubility is a strong indicator of a substance's tendency to persist and accumulate in fatty tissues.

  • Pharmacokinetic Insights: Understanding how chemicals penetrate biological membranes and their distribution patterns within organisms.

  • Ecotoxicological Modeling: Assisting in the prediction of the environmental fate of non-polar substances in the food chain.

  • Regulatory Compliance: Fulfilling specialized data requirements for chemical substances under REACH and various global safety frameworks.
     

Our Testing Methodologies

 

Weshin Inspection Tech employs standardized analytical procedures as outlined in TG 116:

  • Flask Method: The test substance is equilibrated with a standardized lipid (e.g., Glyceryl Trioleate) under controlled agitation and temperature.

  • Phase Separation Excellence: Utilizing high-speed centrifugation or specialized filtration to ensure clear separation between the lipid phase and undissolved matter.

  • Quantitative Analysis: Employing advanced chromatography (HPLC/GC) to accurately determine the saturation concentration within the lipid phase.
     

Why Partner with Weshin Inspection Tech?

 

  • Strict Physiological Relevance: Measurements are typically performed at 37°C to simulate mammalian body conditions, providing data of superior biological relevance.

  • High-Purity Standards: We use high-grade glyceryl trioleate as the reference lipid to ensure reproducibility and consistency in every test.

  • Expert Technical Support: Our team provides tailored solutions for challenging samples, including those with extremely low solubility or complex matrices.


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