OECD TG-118 Determination of the Number-Average Molecular Weight and the Molecular Weight Distribution of Polymers using Gel Permeation Chromatography
OECD GLP Physical-Mechanical Test
WESHIN INSPECTION TECH CO., LTD_

OECD TG 118: Determination of Number Average Molecular Weight and Molecular Weight Distribution of Polymers using GPC

 

Defining the molecular architecture of polymers to ensure regulatory compliance and material excellence.

The environmental fate and biological impact of a polymer are fundamentally linked to its molecular size distribution. At Weshin Inspection Tech , we provide high-precision analysis following OECD Test Guideline 118 (TG 118), utilizing Gel Permeation Chromatography (GPC/SEC) to characterize the molecular weight profile of your polymeric substances.

 

The Importance of Molecular Weight Characterization

 

Accurate GPC data is critical for the risk assessment and regulatory classification of polymers globally:

  • Low Molecular Weight (LMW) Species: Identifying the fraction of components below $1000 \text{ Da}$, which are more likely to be bioavailable and toxicologically active.

  • PLC Criteria Support: Providing essential data to determine if a substance qualifies as a "Polymer of Low Concern."

  • Structural Consistency: Ensuring batch-to-batch uniformity in polymer production and performance.
     

Our Testing Capabilities: GPC / SEC

 

Weshin Inspection Tech employs advanced liquid chromatography systems optimized for size-exclusion:

  • High-Resolution Columns: Utilizing specialized porous matrices to separate polymers based on their hydrodynamic volume.

  • Standardized Calibration: Establishing robust calibration curves with certified reference standards (e.g., Polystyrene, PMMA).

  • Comprehensive Metrics: We report the Number Average Molecular Weight ($M_n$), Weight Average Molecular Weight ($M_w$), and the Polydispersity Index (PDI).
     

Why Partner with Weshin Inspection Tech?

 

  • Technical Expertise: Our laboratory offers various eluent systems to handle complex polymers with different solubility profiles.

  • Detailed Distribution Mapping: We provide high-resolution distribution plots and precise quantification of the percentage of species with molecular weights below 500 and 1000 Daltons.

  • Regulatory Readiness: Our documentation is specifically designed to meet the technical requirements of REACH (EU/Korea/Taiwan) and other international chemical inventory registrations.


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