OECD 471 Bacterial Reverse Mutation Test
Toxicity studies of drugs and chemicals
  • Test Methods/Standards 

    OECD TG-471

  • Test bacterial 

    S. typhimurium TA98
    S. typhimurium A100
    S. typhimurium TA1535
    S. typhimuriumTA1537
    E.coli WP2 uvrA

  • Introduction 

    The objective of this study was to detect mutations in test strains (usually uses Salmonella typhimurium or Escherichia coli) caused by the test substance. Test strains are exposed to the test substance.  If test substance causes mutation,  test strains are able to form colonies that are visible to the human naked eyes on medium.  We will infer from the growth of colonies that whether test substance is a possible carcinogen.