OECD TG-119 Determination of the Low Molecular Weight Content of a Polymer Using Gel Permeation Chromatography
OECD GLP Physical-Mechanical Test
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OECD TG 119: Determination of Low Molecular Weight Content of Polymers using GPC

 

Precisely quantifying low molecular weight fractions to secure global regulatory approval and product safety.

In the regulatory landscape of polymers, the fraction of molecules with a molecular weight below 1000 Daltons is a critical determinant of environmental and human health risk. At Weshin Inspection Tech , we provide specialized analysis following OECD Test Guideline 119 (TG 119) to accurately determine the low molecular weight (LMW) content of your polymeric substances.


The Critical Importance of LMW Content Analysis

 

Determining the LMW fraction is a mandatory step for polymer notification and exemption under many international frameworks:

  • Bioavailability Assessment: Species with M < 1000 Da  are generally considered more bioavailable and capable of crossing biological barriers.

  • PLC (Polymer of Low Concern) Status: Many jurisdictions require LMW content to be below specific thresholds (e.g., 2% or 5%) to qualify for simplified registration or exemptions.

  • Risk Management: Providing evidence to support the safety profile of high-molecular-weight polymers by proving minimal presence of reactive oligomers.
     

Our Advanced GPC Methodology

 

Weshin Inspection Tech utilizes high-performance Size Exclusion Chromatography (SEC/GPC) tailored for LMW detection:

  • Optimized Calibration: Using low-range certified reference standards to ensure maximum accuracy in the 100 to 2000 Dalton region.

  • Quantitative Mapping: Advanced peak integration techniques to calculate the exact mass percentage of species below 500 Da and 1000 Da.

  • Versatile Eluents: Capability to handle diverse polymer types using various organic solvents to ensure complete sample solubility and reliable data.
     

Why Choose Weshin Inspection Tech?

 

  • Compliance-Driven Reporting: Our reports are structured to meet the specific technical requirements of ECHA (REACH), EPA (TSCA), and other national authorities.

  • High-Resolution Separation: We employ high-efficiency columns designed specifically for the sharp resolution of low molecular weight components.

  • Strategic Support: Our technical experts assist you in interpreting LMW data to determine the most favorable regulatory path for your polymer products.


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