OECD TG-125 Nanomaterial Particle Size and Size Distribution of Nanomaterials
OECD GLP Physical-Mechanical Test
WESHIN INSPECTION TECH CO., LTD_

OECD TG 125: Nanomaterial Particle Size and Size Distribution

 

Precision sizing to unlock the potential and safety of manufactured nanomaterials.
 

The unique properties of nanomaterials are fundamentally tied to their microscopic dimensions. At Weshin Inspection Tech , we conduct high-resolution particle size characterization in strict accordance with OECD Test Guideline 125 (TG 125), providing essential data on the size and distribution of substances within the nano-range (1 nm to 100 nm).


The Critical Importance of Particle Size Characterization

 

Accurate sizing is the cornerstone of nanomaterial identification and regulatory compliance:

  • Regulatory Definition Support: Aligning with the European Commission's definition, where a material is classified as "nano" if more than 50% of its particles (by number) fall within the 1 nm – 100 nm range.

  • Toxicological Relevance: Smaller particles have a higher propensity to bypass biological barriers, making size distribution critical for assessing health risks.

  • Material Performance: Particle size dictates key attributes such as surface area, reactivity, dispersion stability, and optical clarity in high-tech applications.

  • Global Compliance Mastery: Fulfilling the specialized data requirements for REACH (Nano-annexes), biocidal products, and national nanomaterial registries.
     

Our Testing Methodologies

 

Weshin Inspection Tech utilizes a comprehensive suite of advanced techniques optimized for nanomaterials:

  • Electron Microscopy (SEM/TEM): Direct visualization of primary particles and statistical count analysis, regarded as the "gold standard" for regulatory dossiers.

  • Dynamic Light Scattering (DLS): Measuring the hydrodynamic diameter of particles in liquid suspensions for rapid screening and stability analysis.

  • Atomic Force Microscopy (AFM): Characterizing particle height and 3D morphology with sub-nanometer resolution.

  • Centrifugal Liquid Sedimentation (CLS): Delivering ultra-high resolution for complex or polydisperse samples by separating particles based on size and density.
     

Why Partner with Weshin Inspection Tech?

 

  • Advanced Sample Preparation: Utilizing standardized ultrasonication and stabilization protocols to accurately measure primary particle size while minimizing artifact aggregation.

  • Shape & Aspect Ratio Analysis: Beyond diameter, we provide detailed insights into particle morphology (e.g., spheres, rods, fibers) to support full structural characterization.

  • Regulatory-Ready Reporting: Our test dossiers feature comprehensive number-based and volume-based distribution plots, designed for seamless integration into international regulatory submissions.


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